Maintaining a Vibrant and Productive Laboratory as a Senior Investigator

James L. Boyer, MD president of the American Association for the Study of Liver Diseases, as well as the International Association for the Study of the Liver, and a senior investigator who runs a vigorous and impactful research program funded by a grant currently in its 40th year. We asked Dr Boyer to discuss his decision to maintain a research program (as opposed to switching his focus to teaching or administration) at this stage of his career. We hope his article, which makes it clear that he has followed his own advice to remain passionate and compellingly interested in research, will be inspiring to investigators at all stages of their careers.